Themed Section: Opioids: New Pathways to Functional Selectivity
نویسندگان
چکیده
KEY RESULTS Tapentadol showed agonist activity at μ receptors and was approximately six times less potent than morphine with respect to KIR3.x current modulation. The intrinsic activity of tapentadol was lower than [Met]enkephalin, morphine and oxycodone, but higher than buprenorphine and pentazocine. Tapentadol inhibited the noradrenaline transporter (NAT) with potency similar to that at μ receptors. The interaction between these two mechanisms of action was additive in individual LC neurons.
منابع مشابه
Themed Section: Opioids: New Pathways to Functional Selectivity
Département de physiologie et biophysique, Institut de pharmacologie de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California in Los Angeles, Los Angeles, CA, USA Correspondences Louis Gendron, Department of Physiology and Biophysics, Faculty of ...
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